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目的:分析蛛网膜下腔出血后脑脊液中可溶性粘附分子与颅内血管痉挛的关系。方法:原发性蛛网膜下腔出血患者19人,正常对照组18人,用ELISA法检测脑脊液中内皮细胞选择凝集素(E-Selectin),细胞间粘附分子一1(ICAM-1),血管细胞粘附分子一1(VCAM-1)和白细胞选择凝集素(L-Selectin)的含量,用TCD探测大脑前、中、后动脉的血流速度。结果:蛛网膜下胜出血后E-Selectin、ICAM-1、VCAM-1均明显升高(P<005),颅内动脉血流速度普遍增快,脑脊液中粘附分子水平升高与颅内血管痉挛密切相关(r=0.67)。结论:蛛网膜下腔出血后脑脊液中可溶性粘附分子水平升高与颅内动脉痉挛的发生密切相关。
Objective: To analyze the relationship between soluble adhesion molecules in cerebrospinal fluid (CSF) and intracranial vasospasm after subarachnoid hemorrhage. Methods: Nineteen patients with primary subarachnoid hemorrhage and 18 normal controls were enrolled in this study. E-Selectin, ICAM-1, (VCAM-1) and leukocyte-selective lectin (L-Selectin) were detected by flow cytometry. TCD was used to detect the blood flow velocity in the anterior, middle and posterior cerebral arteries. Results: The levels of E-Selectin, ICAM-1 and VCAM-1 were significantly increased after subarachnoid hemorrhage (P <0.05), the intracranial arterial blood flow velocity was generally increased, and the level of adhesion molecules in cerebrospinal fluid Vasospasm is closely related (r = 0.67). Conclusion: The elevated levels of soluble adhesion molecules in cerebrospinal fluid after subarachnoid hemorrhage are closely related to the occurrence of intracranial arterial spasm.