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目的:探讨槐杞黄颗粒对儿童紫癜性肾炎血液流变学及血清超敏C-反应蛋白(hs-CRP)的影响。方法:选取72例紫癜性肾炎患儿,随机分为对照组和治疗组,每组36例。两组均予泼尼松、氯雷他定等西医抗炎抗过敏对症治疗,治疗组再予槐杞黄颗粒治疗。观察两组治疗前后血液流变学的变化,检测入院第1天、7天、14天、21天、28天时血清hs-CRP的变化并评估其安全性。结果:治疗后治疗组血浆黏度、血小板最大聚集率、纤维蛋白原水平均低于对照组(P<0.05);治疗组在住院第7天、14天、21天、28天时血清hs-CRP水平均低于对照组(P<0.05);对照组总有效率为72.2%,治疗组总有效率为91.7%,两组比较,差异有统计学意义(χ2=4.600,P=0.032)。两组治疗过程中均未见严重不良反应。结论:槐杞黄颗粒治疗紫癜性肾炎有较好疗效,能有效改善患儿血液流变学,降低血清hs-CRP水平。
Objective: To investigate the effects of Huaiqi Huang granules on hemorrheology and serum hs-CRP in children with purpura nephritis. Methods: 72 cases of children with purpura nephritis were randomly divided into control group and treatment group, 36 cases in each group. Both groups were given prednisone, loratadine and other anti-inflammatory anti-allergic symptomatic treatment of Western medicine group treated with Huai Qi Huang particles. The changes of hemorrheology before and after treatment were observed. The changes of serum hs-CRP on the first day, the seventh day, the fourteenth day, the twenty-one day and the twenty-eighth day were observed and their safety was evaluated. Results: After treatment, the plasma hs-CRP levels in the treatment group were significantly lower than those in the control group (P <0.05). The levels of hs-CRP in the treatment group were significantly higher at 7, 14, 21 and 28 days (P <0.05). The total effective rate was 72.2% in the control group and 91.7% in the treatment group. There was significant difference between the two groups (χ2 = 4.600, P = 0.032). No serious adverse reactions were observed in the two groups during the course of treatment. Conclusion: Huaiqi Huang Granule has a good therapeutic effect on purpuric nephritis, which can effectively improve the hemorrheology and reduce the serum hs-CRP level.