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目的:观察丹参川芎嗪针剂联合高压氧治疗脑卒中患者的临床效果。方法:选取104例脑卒中患者作为研究对象,随机分为观察组和对照组各52例,观察组患者予以丹参川芎嗪针剂联合高压氧治疗,对照组患者单纯予以高压氧治疗,观察比较两组患者的临床疗效、血液动力学变化及神经功能缺损评分情况。结果:观察组患者治疗总有效率为96.2%,明显高于对照组的78.8%,差异具有统计学意义(P<0.05);治疗后,观察组患者的神经功能缺损评分为(12.3±4.8)分,低于对照组的(18.3±4.5)分,差异具有统计学意义(P<0.05);治疗后,观察组患者的全血高切、低切黏度及血浆黏度、红细胞压积改善情况均优于对照组,差异具有统计学意义(P<0.05)。结论:采用丹参川芎嗪针剂联合高压氧治疗脑卒中效果显著,可有效改善患者的神经功能及血液流变学,降低血浆黏度,延缓病情进展,延迟复发,值得临床推广应用。
Objective: To observe the clinical effect of ligustrazine tetramethylpyrazine injection combined with hyperbaric oxygen in patients with stroke. Methods: A total of 104 stroke patients were selected as study subjects and randomly divided into observation group (52 cases) and control group (52 cases). Patients in the observation group were treated with Ligustrazine plus ligustrazine injection and hyperbaric oxygen therapy. Patients in the control group were treated with hyperbaric oxygen therapy alone. Patient’s clinical efficacy, hemodynamic changes and neurological deficit scores. Results: The total effective rate of observation group was 96.2%, which was significantly higher than that of control group (78.8%), the difference was statistically significant (P <0.05); after treatment, the score of neurological deficit in observation group was (12.3 ± 4.8) (18.3 ± 4.5) points lower than that of the control group (P <0.05). After treatment, the high blood pressure and low shear viscosity, plasma viscosity and hematocrit in the observation group were all improved Better than the control group, the difference was statistically significant (P <0.05). Conclusion: The treatment of stroke with Danshen ligustrazine injection combined with hyperbaric oxygen has significant effect, which can effectively improve the neurological function and hemorheology of patients, reduce the plasma viscosity, delay the progression of the disease and delay the recurrence, which deserves clinical application.