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目的:研究平滑肌肉瘤中是否存在血管生成拟态,阐述血管生成拟态的临床意义及相关机制。方法:收集临床和预后资料完整的平滑肌肉瘤组织切片45例,复习切片明确诊断后进行CD34和PAS双重染色,证实肿瘤组织中血管生成拟态的结构,分析血管生成拟态相关的临床意义。结果:45例平滑肌肉瘤中25例(55.6%)具有血管生成拟态。有转移患者和无转移患者血管生成拟态阳性率差别有统计学意义(P<0.05),生存的患者和死亡的患者血管生成拟态阳性率差别也有统计学意义(P<0.01)。Kaplan-Meier生存分析提示有无血管生成拟态肿瘤患者生存时间差异有统计学意义(P<0.05)。结论:平滑肌肉瘤中存在血管生成拟态,血管生成拟态是平滑肌肉瘤患者预后的不利因素,有血管生成拟态的患者易发生转移,预后比无血管生成拟态的患者差。
OBJECTIVE: To study the presence or absence of angiogenic mimicry in leiomyosarcoma and to elucidate the clinical significance and related mechanisms of angiogenesis mimicry. METHODS: Forty-five leiomyosarcoma tissue sections with complete clinical and prognostic data were collected. After the definitive diagnosis, CD34 and PAS staining were performed to confirm the structure of angiogenic mimicry in tumor tissues. The clinical significance of angiogenesis mimicry was analyzed. Results: Among 45 cases of leiomyosarcoma, 25 (55.6%) had angiogenic mimicry. There was a statistically significant difference in the angiogenic mimicry positive rate between metastatic patients and non-metastatic patients (P<0.05), and there was a statistically significant difference in the angiogenic mimicry positive rate between surviving patients and those who died (P<0.01). Kaplan-Meier survival analysis showed that there was a significant difference in survival time between patients with and without angiogenesis mimicry tumors (P<0.05). Conclusion: There is an angiogenic mimicry in leiomyosarcoma, and the mimicry of angiogenesis is an unfavorable factor in the prognosis of patients with leiomyosarcoma. Patients with angiogenic miosis are prone to metastasis and the prognosis is worse than that in patients without angiogenesis mimicry.