肝性骨营养不良是指发生在慢性肝病患者的骨疾息。患者可有骨痛,病理性骨折及椎骨的萎陷。这种合并症,常见于原发性胆汁性肝硬化患者,也可发生在酒精性肝硬化及慢性活动性肝炎息者,尤其在合并胆汁郁积时多见。近年来的研究指出骨营养不良至少包括两种不同的疾病,即骨质疏松症及骨软化。由于发病因素是多种多样的,因而治疗方法也随之不同。在本文中骨软化是指成骨缺陷,即骨质钙化时间延长。而骨质疏松则 Hepatic osteodystrophy refers to bone disease that occurs in patients with chronic liver disease. Patients may have bone pain, pathological fractures and vertebrae collapse. This complication, common in patients with primary biliary cirrhosis, can also occur in patients with alcoholic cirrhosis and chronic active hepatitis, especially in the merger with cholestasis more common. Recent studies indicate that osteodystrophy includes at least two different diseases, osteoporosis and osteomalacia. Because of the variety of morbidities, therapies vary. In this article, osteomalacia refers to osteogenic defects, ie, prolonged calcification of the calcification. While osteoporosis is