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目的:在矽肺大鼠模型中评估使用细菌纤维素、细菌纤维素混合中草提取液治疗矽肺的效果。方法:在体重为180~220 g的大鼠肺部注入50 mg/只的二氧化硅粉尘给大鼠染尘;利用上述各种制剂对大鼠进行治疗,治疗四周后处死,通过观察组织病理学病变、检测脏体系数、全肺胶原含量、全肺干重、全肺游离二氧化硅含量以及检测肺灌洗液中细胞计数及分类来全面评估各种制剂的治疗效果。结果:各种制剂的治疗效果依次为:含细菌纤维素的中草药提取液治疗组>细菌纤维素治疗组>阳性对照组,但是,各检测指标数据与阳性对照组未发现有明显的统计学差异,说明两种制剂的治疗效果不是很明显(P<0.05)。结论:细菌纤维素治疗组稍微低于灌注的二氧化硅粉尘量,这初步表明细菌纤维能有效促进二氧化硅粉尘中肺部组织中排出,这进一步验证了中草药红茶菌中能产生细菌纤维素的木醋杆菌具有生物排尘的机理。
OBJECTIVE: To evaluate the efficacy of bacterial extract of cellulose and bacterial cellulose in the treatment of silicosis in silicotic rat model. Methods: The lungs of rats weighing 180-220 g were dosed with 50 mg of silica dust and the rats were treated with the above preparations. After four weeks of treatment, they were sacrificed, Neutropenia, Nephrotic syndrome, detection of somatic coefficients, total lung collagen content, total lung dry weight, total free lung silica content, and lung cell count in lung lavage were measured to assess the efficacy of various agents. Results: The therapeutic effects of various preparations were as follows: Chinese herbal extract with bacterial cellulose treatment group> bacterial cellulose treatment group> positive control group, however, no significant difference was found between each detection index data and the positive control group , Indicating that the two formulations of the treatment effect is not very clear (P <0.05). Conclusion: Bacterial cellulose treatment group was slightly lower than the amount of silica dust perfusion, which preliminary showed that bacterial fiber can effectively promote the discharge of silica dust in the lung tissue, which further validates the Chinese herbal medicine Kombucha bacteria can produce bacterial cellulose Acetobacter xylinum has the biological dust discharge mechanism.