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为探讨IｇＥ及其介导的Ⅰ型变态反应在急性乙型肝炎发病机理中的作用，对42例急性乙型肝炎病人随机分为治疗组和对照组，并观察了联合抗过敏疗法对急性乙型肝炎的疗效和血清内ＩｇＥ水平及组织胺含量的动态变化。结果发现，治疗组行联合抗过敏疗法后血清内丙氨酸转氨酶(ALT)和总胆红素(T－ＢＩＬ）均比治疗前明显降低（Ｐ＜０．０１），而对照组治疗前后无明显变化；治疗组ALT及Ｔ－ＢＩＬ复常天数明显少于对照组（Ｐ＜０．０１，Ｐ＜０．０5）；无论是对照组或治疗组，治疗前血清内ＩｇＥ水平和组织胺含量均显著高于正常人（Ｐ＜０．０１）；治疗组治疗后ⅠgE水平明显低于治疗前（Ｐ＜０．０1）；对照组无显著性差异（Ｐ＜０．０5）；治疗组治疗后组织胺水平无显著差异，但对照组治疗后组织胺明显高于治疗前（Ｐ＜０．０5）。提示，ＩｇＥ及其介导的Ⅰ型变态反应与急性乙型肝炎的发病机理有一定关系，而且通过联合抗过敏疗法得到进一步证实。
In order to investigate the role of IgE and its mediated type I allergic reactions in the pathogenesis of acute hepatitis B, 42 patients with acute hepatitis B were randomly divided into treatment group and control group, and the combination of anti-allergy therapy for acute B Hepatitis Efficacy and serum IgE levels and histamine content of the dynamic changes. The results showed that the levels of ALT and T-BIL in the treatment group were significantly lower than those before treatment (P <0.01), but no significant difference was found in the control group before and after treatment (P <0.01, P <0.05). No matter in control group or treatment group, serum IgE level and histamine content before treatment were significantly lower than those in control group (P <0.01). The level of IgE in the treatment group was significantly lower than that before treatment (P <0.01), but there was no significant difference in the control group (P <0.05). The treatment group After histamine levels were not significantly different, but histamine after treatment in the control group was significantly higher than before treatment (P <0.05). Tip, IgE and its type Ⅰ allergic reaction and the pathogenesis of acute hepatitis B have a certain relationship, but also through the combination of anti-allergy therapy was further confirmed.