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目的探讨非侵袭性基底细胞癌(NIBCC)与侵袭性基底细胞癌(IBCC)中的细胞凋亡抑制蛋白(Bcl-2)和细胞增殖活性蛋白(ki67)的表达及意义。方法应用免疫组化SP法检测40例基底细胞癌(BCC)石蜡标本(20例NIBCC和20例IBCC)中的Bcl-2、ki67蛋白表达。结果20例NIBCC的Bcl-2均呈强阳性表达,而20例IBCC的Bcl-2的表达则以弱阳性为主。20例NIBCC中,ki67表达则以弱阳性为主,而20例IBCC的ki67呈强阳性表达。结论Bcl-2、ki67可作为判断BCC预后的参考指标,但尚不能作为衡量BCC恶性程度的指标;ki67可作为衡量BCC侵袭性的指标之一。
Objective To investigate the expression and significance of apoptosis-inhibiting protein (Bcl-2) and cell proliferation-activating protein (ki67) in non-invasive basal cell carcinoma (NIBCC) and invasive basal cell carcinoma (IBCC) Methods The expressions of Bcl-2 and Ki67 in 40 cases of basal cell carcinoma (BCC) paraffin specimens (20 cases of NIBCC and 20 cases of IBCC) were detected by immunohistochemical SP method. Results The expression of Bcl-2 in 20 cases of IBC was strongly positive, while that of 20 cases of IBCC was weakly positive. In 20 cases of NIBCC, the expression of ki67 was weakly positive, while that of 20 cases of IBCC was strongly positive. Conclusions Bcl-2 and ki67 can be used as reference indexes to judge the prognosis of BCC, but they can not be used as a measure of malignancy of BCC. Ki67 can be used as a measure of BCC invasiveness.