论文部分内容阅读
目的:探讨联合检测降钙素原(PCT)、C反应蛋白(CRP)水平的改变在新生儿败血症患儿治疗前后的临床意义。方法:收集治疗前后60例新生儿败血症患儿和60例非感染性对照组患儿血清,分别用免疫层析法和免疫比浊法测定血清PCT和CRP含量。结果:抗生素治疗前新生儿败血症患儿血清PCT、CRP水平明显高于对照组(P<0.01),合理抗生素治疗一周后,血清中PCT和CRP水平明显下降,与急性期比较差异有显著性意义(P<0.01)。PCT的敏感性及特异性分别为88.2%、100%;CRP的敏感性及特异性分别为89.5%、70.8%。结论:联合检测新生儿败血症患儿治疗前后PCT、CRP水平的变化可作为病情监测和疗效评价指标。
Objective: To investigate the clinical significance of combined detection of procalcitonin (PCT) and C-reactive protein (CRP) levels in children with neonatal sepsis before and after treatment. Methods: Serum samples from 60 neonates with sepsis and 60 non-infected controls were collected before and after treatment. Serum PCT and CRP levels were measured by immunochromatography and immunoturbidimetry respectively. Results: Serum PCT and CRP levels in neonates with sepsis before antibiotic treatment were significantly higher than those in control group (P <0.01). After one week of rational antibiotic treatment, serum PCT and CRP levels were significantly decreased compared with those in acute stage (P <0.01). The sensitivity and specificity of PCT were 88.2% and 100%, respectively. The sensitivity and specificity of CRP were 89.5% and 70.8% respectively. Conclusion: The changes of PCT and CRP levels in children with neonatal sepsis can be used as indicators of disease surveillance and curative effect before and after treatment.