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本症急性期的诊断依据为:(1)血象有典型改变,呈相对性淋巴细胞增生,周围血出现异型单核细胞。(2)嗜异凝集试验阳性。后一试验对儿童不敏感,因此过去认为年幼儿童本症很少见。近年来证明本症和一种疱疹样病毒(Epstein-Barr病毒,简称EB病毒)有关。这种病毒首先发现于Burkitt氏淋巴瘤,后来用免疫萤光及电子显微镜检查也从传染性单核细胞增多症病人周围血的淋巴母细胞培养中找到,EB病毒抗体在患病早期不出现,而在康复期出现,并显示抗体滴定度逐渐上升。近年来发现儿童EB病毒抗体阳性率逐年上升,因此本文研究了EB病毒抗体和本症的关系,采用全血细胞计数、嗜异凝集、单核细胞增生(mononucleosis)及EB病毒抗体免疫萤光滴定四种试验。
The diagnosis of acute disease based on: (1) blood as a typical change was relative lymphocyte proliferation, peripheral blood mononuclear cells appear. (2) Indigo agglutination test positive. The latter test is not sensitive to children, so in the past that young children with this disease is rare. In recent years proved that the disease and a herpes-like virus (Epstein-Barr virus, referred to as Epstein-Barr virus). This virus was first found in Burkitt’s lymphoma and later by immunofluorescence and electron microscopy was also found in the culture of lymphoblasts from peripheral blood of patients with infectious mononucleosis who did not show up in the early stages of the disease, Appeared in the convalescent period, and showed that the antibody titers gradually increased. In recent years, it was found that the positive rate of EBV antibody increased year by year in children. Therefore, the relationship between Epstein-Barr virus antibody and this disease was studied in this paper. The immunofluorescence titration of Epstein-Barr virus (EBV) was performed by using whole blood cell count, Tests.