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过去15年中对何杰金氏病(HD)的治疗已有了较大进展.由于高剂量,广射野的放射治疗及MOPP(氮芥,长春新硷,甲基苄胼,强的松)方案联合化疗的应用,使HD患者的生存期得以延长,并使早期HD的5年生存率达98%〔1～3〕,约60～90%的早期HD可以治愈.晚期的HD患者5年生存率约60%左右.随着生存期的延长,出现因治疗而引起的晚期合并症的机会增多. 联合化疗的急性副反应取决于所用药的种类.如应用MOPP方案,注射药物后可引起恶心、呕吐,若以环磷酰胺(CTX)取代
Considerable progress has been made in the treatment of Hodgkin’s disease (HD) over the past 15 years due to the high dose of radiotherapy and radiotherapy of MOPP (mechlorethamine, vincristine, methylbenzal, prednisone ) Regimen combined with chemotherapy to prolong the survival of patients with HD and make the 5-year survival rate of early HD was 98% 〔1 ~ 3〕, about 60 ~ 90% of early HD can be cured. Late HD patients 5 The annual survival rate is about 60% .With the prolongation of survival, there is an increased chance of complications due to treatment of advanced complications.Acute side effects of combined chemotherapy depends on the type of drug used.If the MOPP program, after injection of drugs Cause nausea, vomiting, if cyclophosphamide (CTX) replaced