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目的:探讨青黛颗粒治疗溃疡性结肠炎(UC)的机制。方法:应用2,4-二硝基氯苯法建立大鼠UC模型,检测青黛颗粒治疗后UC大鼠结肠组织中超氧化物歧化酶(SOD)、过氧化氢酶(CAT)活性和脂质过氧化产物丙二醛(MDA)的含量变化。结果:青黛颗粒组UC大鼠结肠组织中SOD活性升高(P<0.05),MDA含量显著降低(P<0.05),CAT活性有增高趋势(P>0.05)。结论:青黛颗粒具有清除结肠组织中的氧自由基,抑制脂质过氧化反应的作用。
Objective: To investigate the mechanism of Qingqi Granule in the treatment of ulcerative colitis (UC). METHODS: The rat UC model was established by 2,4-dinitrochlorobenzene method. The activity of superoxide dismutase (SOD), catalase (CAT) and lipids in colon tissue of UC rats after treatment with Qingqi granules were detected. The content of oxidation product malondialdehyde (MDA) changes. RESULTS: The activity of SOD in colonic tissues of UC rats in Qingqi Granules group was increased (P<0.05), MDA content was significantly decreased (P<0.05), and CAT activity was increased (P>0.05). Conclusion: Qingqi granules have the function of removing oxygen free radicals in the colon tissue and inhibiting lipid peroxidation.