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主肺动脉和末梢肺动脉(肺腺泡内动脉—IAA)结构上存在很大差别。前者为弹性动脉;后者则不仅截面积巨大,且包括肌性动脉(MA),部分肌性动脉(PMA)和非肌性动脉(NMA)三种结构,尤以NMA最多.故在维持肺循环低压、低阻、高灌注上起着重要作用.本实验旨在观察探讨不同缺氧时间该两段肺动脉内皮(EC)结构变化的异同及在肺动脉高压发生发展中的意义。Wistar大鼠分为平原对照和连续低压缺氧(5000m)1、7、21和40d组(n=7～12).测肺动脉平均压(mPAP),利用生物测定法记录右肺外动脉环对不同浓度Ach的舒张反应,光镜记录IAA中MA％、PMA％及NMA％和肺泡区φ
The main pulmonary artery and peripheral pulmonary artery (pulmonary acinar artery - IAA) there is a big difference in structure. The former is an elastic artery, while the latter not only has a huge cross-sectional area, but also includes three structures of muscular artery (MA), partial muscular artery (PMA) and non-muscular artery (NMA) Low pressure, low resistance, high perfusion plays an important role.This experiment aims to observe the different hypoxia time the two sections of pulmonary artery endothelial (EC) structure similarities and differences in the occurrence and development of pulmonary hypertension significance. Wistar rats were divided into plain control group and continuous hypobaric hypoxia (5000m) for 1, 7, 21 and 40 days (n = 7-12). Mean pulmonary artery pressure (mPAP) was measured and the right external pulmonary artery ring The relaxation responses of Ach at different concentrations were recorded by light microscopy. The percentages of MA%, PMA%, NMA% and alveolar zone φ