本文报道1例口服避孕药所致继发性甲状旁腺功能亢进症(甲旁亢)。患者女性,41岁。1963年因甲状腺囊肿曾作甲状腺部分切除,术后服用甲状腺激素,甲状腺功能一直正常。自1965年起,停服甲状腺激素,而口服炔诺酮(norethindrone)和炔雌醇甲醚(mestranol)的混合避孕药。患者每日饮牛奶1～2杯,无肾结石及其他肾脏疾病、溃疡病、吸收不良及口服抗酸剂等历史。亦无软弱、骨痛及手足搐搦等症状。1974年5月检查甲状腺功能正常。实验室检查发现低血磷症,血清总钙偏低,为4.3(正常4.4～5)mEq/L,血氯108～111mEq/L,甲状旁腺激素(PTH)增高,为308±54.3(正常228±92)ng/ml。尿中环磷腺甙(cAMP)排泄增高,为4.67±0.76(正常2.86±0.88)nmol/mg 肌酐;1小时内输注 PTH 250 U 后,cAMP 排泄略增加。而晨间空腹血钙及24小时尿钙排泄正常。血清镁、白蛋白、蛋白电泳及游离钙正常。几种骨代谢检查及~(99m)Tc 二磷酸盐骨扫描正常,碱性磷酸酶及25羟胆骨化醇正常。当加用或单独用维生素 D This article reports 1 case of oral contraceptives caused by secondary hyperparathyroidism (hyperparathyroidism). Female patient, 41 years old. 1963 Thyroid cysts have been partial thyroidectomy, postoperative thyroid hormone administration, thyroid function has been normal. Since 1965, thyroid hormones have been stopped and oral contraceptives containing norethindrone and mestranol have been discontinued. Patients drink 1 to 2 cups of milk a day, no kidney stones and other kidney diseases, ulcer disease, malabsorption and oral antacid history. No weakness, bone pain and tetany and other symptoms. 1974 May check thyroid function is normal. Laboratory tests revealed hypophosphatemia with low total serum calcium of 4.3 (normal 4.4 to 5) mEq / L, blood chlorine of 108 to 111 mEq / L and elevated PTH of 308 ± 54.3 (normal 228 ± 92) ng / ml. Urinary excretion of cAMP was 4.67 ± 0.76 (normal 2.86 ± 0.88) nmol / mg creatinine; cAMP excretion was slightly increased after infusion of 250 u PTH within 1 hour. The morning fasting serum calcium and 24-hour urinary calcium excretion normal. Serum magnesium, albumin, protein electrophoresis and free calcium normal. Several bone metabolism tests and ~ (99m) Tc diphosphate bone scans were normal with alkaline phosphatase and 25 hydroxycholecalciferol normal. When adding or using vitamin D alone