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1例56岁男性患者因病毒性脑膜炎给予阿昔洛韦0.5 g溶于250 ml生理盐水,3次/d静脉滴注及甘露醇125ml,4次/d静脉滴注治疗。第5天加用七叶皂苷钠20 mg溶于250 ml生理盐水,1次/d静脉滴注,滴速60滴/min,约60 min输注完毕。输注完毕约8 h后,患者出现耳部闷胀不适、耳鸣及对声音分辨能力下降。次日耳部不适感和耳鸣消失,声音分辨能力下降无明显改善。纯音电测听检查示双耳高频听力中度受损,感音神经性听力减退。4 d后再次应用七叶皂苷钠,剂量及用法同前,约10 h后再次出现听力下降、耳部不适、耳鸣。次日耳部不适感及耳鸣均消失,但声音分辨能力下降无明显缓解。给予维生素C、复合维生素B,约2个月后患者听力明显恢复。
A 56-year-old man with a history of viral meningitis was given 0.5 g of acyclovir dissolved in 250 ml of normal saline, 3 times / d intravenously and mannitol 125ml intravenously 4 times / d. On the 5th day, sodium aescinate 20 mg was dissolved in 250 ml normal saline, once / d intravenously. The drip rate was 60 drops / min and the infusion was completed in about 60 minutes. About 8 h after the infusion, the patient experienced irritation and discomfort of the ear, tinnitus, and decreased ability to resolve sounds. The next day the ear discomfort and tinnitus disappeared, sound resolution decreased no significant improvement. Pure tone audiometry showed high frequency hearing loss in both ears, sensorineural hearing loss. 4 days after the application of sodium aescinate again, the same dose and usage, about 10 h again after hearing loss, ear discomfort, tinnitus. The next day the ear discomfort and tinnitus disappeared, but no significant reduction in voice resolution decreased. Given vitamin C, vitamin B, about 2 months after the patient’s hearing recovery significantly.