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脉络膜新生血管(CNV)是引起视力严重损害的常见原因之一,其发生发展是一个多因子调控、多细胞参与的复杂过程。环氧化酶-2(COX-2)是诱导型环氧化酶,是前列腺素生物合成途径的关键酶。COX-2通过调节血管内皮生长因子(VEGF)的合成及生理功能的发挥、内皮细胞的移行和凋亡,在新生血管的形成过程中起重要作用。近期研究证实,COX-2参与了CNV的形成过程,其抑制剂能够抑制CNV的发生发展,为预防和治疗CNV性疾病提供了新的方向。
Choroidal neovascularization (CNV) is one of the most common causes of serious visual impairment. The occurrence and development of it is a complex process involving multi-factor regulation and multicellular involvement. Cyclooxygenase-2 (COX-2) is an inducible cyclooxygenase that is a key enzyme in the prostaglandin biosynthesis pathway. COX-2 plays an important role in the formation of neovascularization by regulating the synthesis and physiological function of vascular endothelial growth factor (VEGF), the migration and apoptosis of endothelial cells. Recent studies confirm that COX-2 participates in the formation of CNV and its inhibitors can inhibit the occurrence and development of CNV, providing a new direction for the prevention and treatment of CNV diseases.