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目的:考察莪术油眼用凝胶对家兔单纯疱疹病毒性角膜炎的治疗。方法:采用单纯性疱疹病毒HSV-I感染家兔角膜,建立体内病毒感染模型,家兔分别用莪术油眼用凝胶、阿昔洛韦、生理盐水治疗10天,眼角膜每天经荧光素钠染色后,裂隙灯观察药物对家兔病毒性角膜炎模型的治疗作用。结果:与模型组相比,莪术油眼用凝胶和阿昔洛韦组均能有效地治疗单纯疱疹病毒性角膜炎,减轻角膜病变程度,缩短平均治愈时间,其疗效与阿昔洛韦组相似(P>0.05)。结论莪术油眼用凝胶对单纯疱疹病毒性角膜炎有明显的治疗作用。
Objective: To investigate the treatment of herpes simplex virus keratitis in rabbits with zedoary eye gel. METHODS: The rabbit cornea was infected with herpes simplex virus HSV-I to establish a virus infection model in vivo. The rabbits were treated with zedoary oil eye gel, acyclovir and saline for 10 days. The cornea received daily sodium fluorescein. After staining, the slit lamp was used to observe the therapeutic effect of the drug on a rabbit model of viral keratitis. RESULTS: Compared with the model group, the zedoary ophthalmic gel and the acyclovir group were effective in the treatment of herpes simplex virus keratitis, reducing the degree of corneal disease and shortening the average healing time. Its curative effect was similar to that of the acyclovir group. Similar (P>0.05). Conclusion Ezhu ophthalmic gel has obvious therapeutic effect on herpes simplex keratitis.