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近十年来,许多实验室相继证明,啮齿类动物和人体内存在着一种不必事先致敏,不依赖抗休和补体的自然细胞毒细胞,命名为自然杀伤细胞(Natural Killer Cell-NK)。 Thomas提出的免疫监视概念认为,健全的免疫系统能够消灭机体自发的或致癌剂诱发癌变的细胞,使肿瘤被控制在早期阶段。一旦个休存在先天性或获得性免疫抑制,则癌细胞迅速增殖,导致癌症的发生。参与免疫反应的杀伤性细胞包括免疫细胞毒T细胞(Tc细胞)、巨噬细胞,抗体依赖细胞毒细胞(K细胞)以及自然杀伤细胞(NK细胞)。 NK细胞属于淋巴细胞的一种亚群,它有一套特殊的细胞表面标志和形态特征,通过
In the past decade, many laboratories have successively demonstrated that natural killer cells (Natural Killer Cell-NK) exist naturally in rodents and the human body and do not require prior sensitization and do not rely on anti-null and complement. The concept of immunosurveillance put forward by Thomas believes that a sound immune system can eliminate cells that are spontaneous or carcinogen-induced cancerous, so that the tumor is controlled at an early stage. Once there is congenital or acquired immunosuppression, cancer cells rapidly proliferate, leading to cancer. Killer cells involved in the immune response include immune cytotoxic T cells (Tc cells), macrophages, antibody-dependent cytotoxic cells (K cells), and natural killer cells (NK cells). NK cells belong to a subpopulation of lymphocytes and have a special set of cell surface markers and morphological characteristics.