钙通道配基有激动剂和拮抗剂之分,Bechem等在研究二者的差异时指出,由于它们具有共同的高亲和力结合位点,双氢吡啶类作用后引起的是激动或拮抗效应,最终要依膜电位的变化而定。研究者表明,在神经之中,它们的效应有赖于细胞内内源性GTP的浓度和一组GTP结合蛋白的活化状态。他们在大鼠背根神经节细胞体外培养中研究钙通道配基对Ba离子流的作用时,发现在一定的条件下,双氢吡啶类和非双氢 Calcium channel ligands have agonist and antagonist points, Bechem and others in the study of the difference between the two pointed out that because they have a common high-affinity binding sites, dihydropyridines caused by the agonistic or antagonistic effect, and ultimately According to changes in membrane potential may be. Researchers have shown that among nerves, their effects depend on the concentration of intracellular endogenous GTP and the activation state of a group of GTP-binding proteins. Their study of the effects of calcium channel ligands on Ba ion currents in rat dorsal root ganglion cells cultured in vitro found that under certain conditions, dihydropyridines and non-dihydrogen