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Mern 细胞对聚肌胞超诱导的干扰素反应比HF细胞的低57倍,出现时间晚6 小时,干扰素mRNA 转录高峰量低10～100倍,但从胞浆干扰素mRNA 高峰到干扰素活性高峰之间相差则同为6小时,干扰素mRNA在胞浆中的降解动态也基本相同;上述干扰素反应差异的本质在转录前水平;两种细胞均主要产生β干扰素,虽也产生少量α干扰素,但其mRNA在胞浆中含量低,并迅速降解。
Mern cells showed a 57-fold lower induction of poly-myeloid-induced IFN than HF cells, a 6-hour late appearance and a 10-100-fold decrease in the peak amount of interferon mRNA transcripts, but from the peak of cytoplasmic interferon mRNA to interferon activity The difference between the peak is the same as 6 hours, interferon mRNA in the cytoplasm degradation dynamics are basically the same; the nature of the difference in the above interferon response at the pre-transcriptional level; both cells are mainly produced interferon beta, although also produced a small amount Alpha interferon, but its mRNA is low in the cytoplasm and rapidly degrades.