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本文对一次性口服常用剂量碘油胶丸(0.4或0.6克)防治地方性甲状腺肿所出现的药物反应作了观察。服药482人,药物反应发生率为33.82%。反应类型以碘中毒反应为主,变态反应为次,其出现频数分别为81.96%和14.07%。药物反应出现最早的是在服药后5分钟,最迟的在服药后53小时。临床表现主要有头晕、颊部酸痛、咽干、流涕,少数出现眼睑和口唇水肿。大部分无需特殊治疗,能自行好转。同时,对服药前与服药后24、48小时的尿碘作了动态观察。认为:采用小剂量分次服药的方法,可利于机体对碘的吸收、储存和利用,减少浪费;又可避免和减少药物反应的发生。
In this paper, a one-time oral dose of commonly used iodized oil capsules (0.4 or 0.6 g) prevention and treatment of endemic goiter drug reactions were observed. Taking 482 people, the incidence of drug reaction was 33.82%. The type of reaction was mainly iodine poisoning, and the frequency of allergy was 81.96% and 14.07% respectively. The earliest response to the drug was taken 5 minutes after taking the medication and 53 hours after the last dose. Clinical manifestations are mainly dizziness, cheek pain, dry throat, runny nose, a small number of eyelids and lip edema. Most do not need special treatment, can improve on their own. At the same time, 24,48 hours before taking the medication and urine iodine made a dynamic observation. It is considered that the method of taking small doses and taking medicine in time can help the body absorb, store and utilize iodine, reduce waste, and avoid and reduce the occurrence of drug reactions.