目的探讨脑外伤与胶质瘤在病因学上有无关系。方法报告一例脑外伤后原位发生胶质母细胞瘤的患者,介绍其临床特征,影像学特点,术中所见及病理特点,并复习相关文献。结果本病例完全符合文献中关于脑外伤后胶质瘤的判定标准。结论脑外伤后发生胶质瘤尽管少见,但是有可能的,脑外伤可能是在已有基因改变的情况下起到辅助致癌因素的作用。 Objective To investigate the relationship between brain injury and glioma in etiology. Methods A case of glioblastoma in situ was reported after traumatic brain injury. The clinical features, imaging features, intraoperative findings and pathological features were reviewed. Relevant literatures were reviewed. The results of this case fully in line with the literature on the determination of glioma after traumatic brain injury criteria. Conclusions Despite the rare occurrence of gliomas following traumatic brain injury, it is possible that traumatic brain injury may play a role as ancillary to carcinogenic factors in the context of existing genetic alterations.