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AIM:To investigate the relationship between insulin-likegrowth factor-Ⅰ,-Ⅱ (IGF-Ⅰ and IGF-Ⅱ),IGF-binding protein 3(IGFBP-3) and Child-Pugh score in patients with liver cirrhosis,and to search for potential clinical markers of liver function.METHODS:Forty-four patients with advanced liver cirrhosisof viral origin were divided into 3 groups according to severityof cirrhosis (Child-Pugh score) and 38 healthy subjectsserved as controls.Serum levels of IGF-Ⅰ,IGF-Ⅱ and IGFBP-3 were measured by immunoradiometric assay.RESULTS:Serum IGF-Ⅰ,IGF-Ⅱ and IGFBP-3 levels weresignificantly lower in patients with cirrhosis than in controls,and serum concentrations of IGF-Ⅰ,IGF-Ⅱ and IGFBP-3 wereassociated with the severity of liver dysfunction,and droppedsharply during the progression of liver failure.Among these3 parameters,serum IGF-Ⅱ was the most sensitive andeffective indicator for liver dysfunction.Concentrations ofIGF-Ⅰ <30 ng/mL,IGF-Ⅱ <200 ng/mL and IGFBP-3 <6 ng/mLimplied a negative prognosis for patients with liver cirrhosis.CONCLUSION:Serum IGF-Ⅰ,IGF-Ⅱ and IGFBP-3 may providea new dimension in the assessment of liver dysfunction.Combined detection of serum IGF-Ⅰ,IGF-Ⅱ and IGFBP-3with Child-Pugh score is more effective in predicting prognosisthan Child-Pugh score alone.
AIM: To investigate the relationship between insulin-likegrowth factor-I, -II (IGF-I and IGF-II), IGF-binding protein 3 (IGFBP-3) and Child-Pugh score in patients with liver cirrhosis, and to search for potential clinical markers of liver function. METHODS: Forty-four patients with advanced liver cirrhosis of viral origin divided into 3 groups according to severity of cirrhosis (Child-Pugh score) and 38 healthy subjectsserved as controls. Levels of IGF-I, IGF -II and IGFBP-3 were measured by immunoradiometric assay .RESULTS: Serum IGF-I, IGF-II and IGFBP-3 levels weresignificantly lower in patients with cirrhosis than in controls, and serum concentrations of IGF- I, IGF- II and IGFBP -3 wereassociated with the severity of liver dysfunction, and dropped sharply during the progression of liver failure. Amm these3 parameters, serum IGF-II was the most sensitive andeffective indicator for liver dysfunction. Confidence ofIGF-I <30 ng / mL, IGF- <200 ng / mL and IGFBP-3 <6 ng / mL impli ed a negative prognosis for patients with liver cirrhosis. CONCLUSION: Serum IGF-I, IGF-II and IGFBP-3 may provide a new dimension in the assessment of liver dysfunction. Detection of serum IGF-I, IGF- Child-Pugh score is more effective in predicting prognosisthan Child-Pugh score alone.