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本研究用咖啡酸、阿魏酸和ＣＡ－１２０１ 对ＥＴ－１ 生物效应的拮抗作用进行了探讨。结果表明：１．咖啡酸、阿魏酸和ＣＡ－１２０１ 在０．１～１００ ｍ ｇ／ｋｇ 剂量范围内，对ＥＴ－１ 引起的小鼠死亡有明显的保护作用，该作用存在剂量依赖性；２．三种药物对 ＥＴ－ １ 缩血管效应有明显的拮抗作用，咖啡酸和ＣＡ－１２０１拮抗效能相近，而阿魏酸的拮抗效能强于咖啡酸和ＣＡ－１２０１；３．三种药物均能拮抗ＥＴ－１ 的升血压作用，与对照组相比，该作用有显著性意义；４．三种药物对 ＥＴ－１ 致家兔血管平滑肌细胞增殖有明显的抑制作用，该作用具剂量依赖性。结论：咖啡酸、阿魏酸和 ＣＡ－１２０１ 能有效地拮抗ＥＴ－１ 的生物效应，是一类新的ＥＴ 拮抗剂
In this study, the antagonistic effects of caffeic acid, ferulic acid and CA-1201 on the biological effects of ET-1 were investigated. The result shows: 1. Caffeic acid, ferulic acid and CA-1201 had a protective effect on ET-1-induced mouse death in the dose range of 0.1 ~ 100 m g / kg, and the effect was dose-dependent.2. The three drugs showed obvious antagonism on the vasoconstrictive effect of ET-1. The antagonistic effects of caffeic acid and CA-1201 were similar, but the antagonistic potency of ferulic acid was stronger than that of caffeic acid and CA-1201.3. The three drugs can antagonize the ET-1 blood pressure, compared with the control group, the role of significant; 4. The three drugs significantly inhibited the proliferation of vascular smooth muscle cells induced by ET-1 in a dose-dependent manner. CONCLUSION: Caffeic acid, ferulic acid and CA-1201 can effectively antagonize the biological effects of ET-1 and are a new class of ET antagonists