论文部分内容阅读
抗真菌药物的临床应用越来越广泛,加之多数药物特异性不强,在作用于真菌细胞的同时也易对人体细胞产生毒性作用;此外,临床治疗真菌感染的药物有限,且用药剂量较大、疗程长、不良反应较多及毒性较大,影响了临床应用。近年来新靶向剂型、新作用靶位的药物相继上市,但真正安全有效的为数尚少。掌握各类抗真菌药物的代谢动力学和药效学(PK/PD)特点及不良反应,对于临床合理选择和应用至关重要。一、抗真菌药的分类及作用机制抗真菌药物主要包括:(1)多烯类:两性霉素 B(AmB)、制霉菌素、克念霉素、帕曲霉素、灰黄霉素
The clinical application of antifungal drugs is more and more widespread, combined with the majority of drug specificity is not strong, in the role of fungal cells but also easy to produce toxic effects on human cells; In addition, the clinical treatment of fungal infections of drugs is limited, and a larger dose , Long course of treatment, more adverse reactions and toxicity, affecting the clinical application. In recent years, new targeted dosage forms, new target drugs have been listed, but the real number of safe and effective few. To master all kinds of antifungal pharmacokinetics and pharmacodynamics (PK / PD) characteristics and adverse reactions, for the clinical rational choice and application is essential. First, the classification of antifungal agents and mechanism of action Antifungal agents include: (1) polyene: amphotericin B (AmB), nystatin, creomycin, amikacin, griseofulvin