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淋巴瘤是一组常见的淋巴造血系统肿瘤,免疫耐受在其发生发展中具有重要的作用。吲哚胺2,3-双加氧酶(indoleamine 2,3-dioxygenase,IDO)是细胞内色氨酸分解的限速酶,肿瘤微环境中,IDO活性增高,导致区域色氨酸耗竭,代谢产物犬尿氨酸蓄积,抑制效应T细胞和自然杀伤(natural killer,NK)细胞增殖和功能,激活调节性T(regulatory T,Treg)细胞,产生免疫逃逸,从而促进淋巴瘤的发生与发展。本文阐述了IDO的生物学特性、与免疫逃逸关系,并对IDO在淋巴瘤的预后及治疗中的作用进行了综述。
Lymphoma is a group of common lymphoid hematopoietic system tumors, and immune tolerance plays an important role in its development. Indoleamine 2,3-dioxygenase (IDO) is the rate-limiting enzyme of tryptophan degradation in cells. In the tumor microenvironment, IDO activity is increased, resulting in the depletion and metabolism of tryptophan in the region. The product kynurenine accumulation inhibits the proliferation and function of effector T cells and natural killer (NK) cells, activates regulatory T (Treg) cells, and produces immune escape, thereby promoting the occurrence and development of lymphoma. This article describes the biological characteristics of IDO and its relationship with immune escape, and reviews the role of IDO in the prognosis and treatment of lymphoma.