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目的分析他汀类药物在临床应用中的副作用,以指导临床合理用药。方法分析91例采用他汀类药物进行临床治疗并出现药物副作用的患者的临床资料。结果 421例患者中91例出现副作用,占21.62%,副作用包括神经肌肉、泌尿系统、皮肤以及消化系统等。他汀类药物治疗3个月内出现副作用,占91.21%。单一采用他汀类药物的患者共33例,占36.26%;合并用药患者58例,占63.74%。用辛伐他汀治疗的患者发生副作用的比例最高,共50例,占54.95%,显著高于其他类型他汀类药物(P<0.05)。结论他汀类药物是临床常用调脂药物,但因需采用联合用药等因素,导致其副作用发生率较高。为保证用药安全,在他汀类药物治疗中应当密切对患者的临床表现进行观察,掌握用药指征,尽可能减少副作用,保证用药安全。
Objective To analyze the side effects of statins in clinical application to guide clinical rational use of drugs. Methods The clinical data of 91 patients who were treated with statins and had side effects were analyzed. Results Among the 421 patients, 91 cases had side effects, accounting for 21.62%. Side effects included neuromuscular, urological, skin and digestive system. Side effects occurred within 3 months of statin treatment, accounting for 91.21%. A total of 33 patients with statins alone, accounting for 36.26%; 58 patients with combined medication, accounting for 63.74%. Patients treated with simvastatin had the highest proportion of side effects, a total of 50 patients (54.95%), significantly higher than other types of statins (P <0.05). Conclusion Statins are commonly used in clinical lipid-lowering drugs, but the combination of drugs and other factors need to be used, resulting in a higher incidence of side effects. In order to ensure the safety of medication, the clinical manifestations of patients should be closely observed in statin therapy, the indications for medication should be grasped, the side effects should be minimized to ensure the safety of medication.