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目的观察托吡酯片在小儿癫痫中的应用效果及对患儿预后的影响。方法选取濮阳市妇幼保健院2012年12月至2014年12月收治的80例癫痫患儿作为研究对象,按随机数字表法分为对照组与观察组,每组40例。对照组给予奥卡西平治疗,观察组给予托吡酯片治疗,两组均治疗12~24周,随访6个月,记录随访结果,观察两组患者治疗效果,统计两组不良反应发生率。结果观察组完全控制20例,显效11例,好转7例,总有效率为95.00%,与对照组的72.50%比较差异有统计学意义(P<0.05);观察组感觉异常1例,胃肠道反应1例,嗜睡1例,不良反应发生率为7.50%,与对照组的32.50%比较差异有统计学意义(P<0.05)。结论在癫痫患儿的临床干预中应用托吡酯片治疗方案,临床治疗有效率高,不良反应发生率低,安全性高,值得推广。
Objective To observe the effect of topiramate tablets in children with epilepsy and prognosis of children. Methods Eighty children with epilepsy who were treated in Puyang MCH hospital from December 2012 to December 2014 were selected and divided into control group and observation group according to random number table method, with 40 cases in each group. The control group was treated with oxcarbazepine. The observation group was treated with topiramate. The patients in both groups were treated for 12-24 weeks and followed up for 6 months. The follow-up results were recorded. The therapeutic effect was observed in both groups. The incidence of adverse reactions was calculated. Results The observation group had complete control of 20 cases, 11 cases markedly improved and 7 cases improved. The total effective rate was 95.00%, which was significantly different from that of the control group (72.50%, P <0.05) 1 case of tract reaction and 1 case of drowsiness. The incidence of adverse reactions was 7.50%, which was significantly different from that of the control group (32.50%, P <0.05). Conclusion The clinical intervention in children with epilepsy topiramate tablets treatment options, clinical treatment of high efficiency, low incidence of adverse reactions, high safety, it is worth promoting.