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目的研究雌孕激素序贯治疗对人工流产不全的作用。方法将120例人工流产吸刮术后不全流产患者随机分为3组,治疗组给予雌孕激素序贯联合治疗,清宫组给予再次清宫治疗,对照组予中药生化汤治疗,观察三组患者治疗效果及子宫恢复情况。结果治疗组、对照组、清宫组治疗有效率分别为75.0%(30/40)、50.0%(20/40)和92.5%(37/40),差异有统计学意义(P<0.05);两两比较显示,对照组治疗有效率明显低于治疗组和清宫组,治疗组治疗有效率明显低于清宫组,差异有统计学意义(P均<0.05)。治疗组、清宫组、对照组治疗后阴道不规则流血时间分别为(8.3±2.5)、(10.7±4.8)和(14.5±5.1)d,差异有统计学意义(P<0.01);两两比较显示,治疗组治疗后阴道不规则流血时间明显少于清宫组和对照组,清宫组治疗后阴道不规则流血时间明显少于对照组,差异有统计学意义(P均<0.05)。治疗组、清宫组、对照组治疗后月经复潮时间分别为(28.4±5.5)、(33.2±6.7)和(37.3±8.6)d,差异有统计学意义(P<0.01);两两比较显示,治疗组治疗后月经复潮时间明显少于清宫组和对照组,清宫组治疗后月经复潮时间明显少于对照组,差异有统计学意义(P均<0.05)。三组不良反应发生率相比较差异无统计学意义。结论雌孕激素序贯治疗应用人工流产不全疗效较好,副作用小,治疗后的子宫恢复较再次清宫及中药组快,值得临床推广应用。
Objective To study the effect of sequential treatment of estrogen and progesterone on induced abortion. Methods 120 cases of incomplete abortion after induced abortion were randomly divided into three groups. The treatment group was treated with sequential combination of estrogen and progesterone, the Qing-treated group was treated with Qing-hui treatment again. The control group was treated with Chinese herbal biochemical soup, and the three groups of patients were treated Effect and recovery of the uterus. Results The effective rates of treatment group, control group and QingGong group were 75.0% (30/40), 50.0% (20/40) and 92.5% (37/40), respectively, with significant difference (P <0.05) The comparison between the two groups showed that the effective rate of the control group was significantly lower than that of the treatment group and the Qinggong group, and the effective rate of the treatment group was significantly lower than that of the Qing group (P <0.05). The time of irregular vaginal bleeding after treatment in treatment group, Qing palace group and control group were (8.3 ± 2.5), (10.7 ± 4.8) and (14.5 ± 5.1) days, respectively, with statistical significance (P <0.01) The results showed that the time of vaginal irregular bleeding after treatment in the treatment group was significantly less than that in the Qing group and the control group. The time of irregular vaginal bleeding after treatment in the Qing group was significantly less than that in the control group (P <0.05). The time of menstrual resuscitation in treatment group, Qing palace group and control group were (28.4 ± 5.5), (33.2 ± 6.7) and (37.3 ± 8.6) d, respectively, with statistical significance (P <0.01) , The treatment group after menstruation recuperation time was significantly less than the Qing group and control group, qinggong group after menstruation recuperation time was significantly less than the control group, the difference was statistically significant (P all <0.05). The incidence of adverse reactions in the three groups showed no significant difference. Conclusions The sequential treatment of estrogen and progesterone by artificial abortion is effective and the side effects are small. The uterine recovery after treatment is faster than that of the curettage group and the traditional Chinese medicine group again, which deserves clinical application.