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在多药抗性疟原虫存在的地区,治疗急性单纯性恶性疟原虫感染前,了解病人经抗疟药预治的比率和原虫体外药物敏感性对于选择适当的治疗方案是必要的。因此,作者检测了411名泰国无并发症恶性疟病人血中甲氟喹、奎宁和青蒿素的基础水平及疟原虫分离株对这些药物的体外敏感性。治疗开始前抽取病人血样。体外药敏试验采用改良的
In areas where MDR-Plasmids are present, it is necessary to know the ratio of patients pre-treated with antimalarial drugs and the drug sensitivity of protozoa in vitro before the treatment of acute pure Plasmodium falciparum infection for the selection of appropriate treatment regimens. Therefore, the authors tested the basal levels of mefloquine, quinine and artemisinin in 411 blood from patients with uncomplicated falciparum malaria in Thailand and the in vitro susceptibility of the malaria isolates to these drugs. Patient blood samples were drawn before treatment started. In vitro susceptibility testing using modified