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目的分析左卡尼丁治疗慢性充血性心力衰竭(CHF)临床疗效。方法 100例慢性CHF患者,采用双盲法分为观察组和对照组,各50例。对照组采用常规治疗,观察组在常规治疗基础上加用左卡尼丁治疗。比较两组治疗前后左室射血分数、心率(HR)、收缩压(SBP)、舒张压(DBP)、氨基末端脑钠肽前体(NT-proBNP)水平及治疗效果和不良反应情况。结果治疗后,观察组左室射血分数高于对照组,NT-proBNP水平低于对照组,差异有统计学意义(P<0.05);观察组HR、SBP、DBP均优于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率(90.00%)高于对照组(72.00%),差异有统计学意义(P<0.05)。两组患者均未出现明显不良反应。结论左卡尼丁用于慢性CHF中,能显著改善患者HR、血压、左室射血分数,降低血清NT-proBNP水平,提高治疗效果,值得推广。
Objective To analyze the curative effect of left carnitine on chronic congestive heart failure (CHF). Methods 100 cases of chronic CHF patients were divided into observation group and control group by double-blind method, each 50 cases. The control group with conventional treatment, the observation group on the basis of conventional treatment plus left carnitine treatment. The left ventricular ejection fraction, heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and NT-proBNP level were compared between the two groups before and after treatment. The therapeutic effects and adverse reactions were also compared. Results After treatment, left ventricular ejection fraction in the observation group was higher than that in the control group, and NT-proBNP level was lower in the observation group than in the control group (P <0.05); HR, SBP and DBP in the observation group were better than those in the control group There was statistical significance (P <0.05). The total effective rate of observation group (90.00%) was higher than that of control group (72.00%), the difference was statistically significant (P <0.05). No significant adverse reactions occurred in both groups. CONCLUSIONS: L-Carnitine is used in chronic CHF and can significantly improve HR, blood pressure, left ventricular ejection fraction, decrease serum NT-proBNP levels and improve the therapeutic effect, which is worth promoting.