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目的 :研究E -钙粘附素在金黄地鼠颊囊癌变过程中的表达 ,探讨E -钙粘附素与肿瘤的发生、发展之间的关系及其临床意义。方法 :采用免疫组化技术检测 2 3例金黄地鼠颊囊正常黏膜 ,2 2例上皮单纯增生 ,2 2例上皮异常增生 ,2 3例鳞癌组织中E -钙粘附素的表达。结果 :E -钙粘附素在口腔正常黏膜上皮中均匀广泛被染色 ,上皮异常增生及鳞癌中E -钙粘附素呈明显下调表达 ,且与正常黏膜相比有显著性差异 (P <0 .0 5 )。结论 :E -钙粘附素的下调表达是口腔黏膜鳞癌发生发展的早期变化 ,可作为口腔黏膜恶变潜能的重要标志物。
Objective: To study the expression of E - cadherin in the process of carcinogenesis of golden hamster cheek pouch and to explore the relationship between E - cadherin and the occurrence and development of tumor and its clinical significance. Methods: Immunohistochemistry was used to detect the expression of E - cadherin in 23 cases of golden hamster cheek pouch normal mucosa, 22 cases of epithelial hyperplasia, 22 cases of epithelial dysplasia and 23 cases of squamous cell carcinoma. Results: E - cadherin was widely and stained extensively in the normal mucosal epithelium of oral mucosa. The abnormal expression of E - cadherin in epithelial dysplasia and squamous cell carcinoma was significantly lower than that in normal mucosa (P < 0 .0 5). Conclusion: The down - regulated expression of E - cadherin is an early change in the development of oral mucosal squamous cell carcinoma and may be used as an important marker of the malignant potential of oral mucosa.