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我们以灭活卡介苗(BCG)联合其他药物治疗肾病型的原发性肾小球肾炎(PGN),60例(大部对激素不敏感)中完全和基本缓解者分别为32和16例。对病理类型和临床表现相仿者,BCG 组疗效远胜于对照组。随访1～2年以上的15例中,13例完全缓解。对24例 PGN 病人单核细胞吞噬功能检查的结果表明,PGN 组明显低于正常对照组,经 BCG 接种3周后可使之恢复正常。对家兔改良的慢性血清病肾炎(呈系膜增殖性)模型接种 BCG 的结果显示,BCG 组肾小球炎症明显轻于对照组。以上结果提示 BCG 接种有助于 PGN 的治疗。
We treated 32 patients with primary glomerulonephritis (PGN) with nephropathy by inactivating BCG plus other drugs, and 32 (16%) and complete remission (60 patients), mostly hormone insensitive, respectively. For pathological types and clinical manifestations were similar, BCG group far better than the control group. Of the 15 patients who were followed up for 1 to 2 years, 13 were completely relieved. The results of phagocytosis of mononuclear cells in 24 PGN patients showed that PGN group was significantly lower than that of normal control group and returned to normal after 3 weeks BCG inoculation. Inoculation of BCG in rabbits with modified chronic seronegative nephritis (mesangial proliferative) model showed that glomerular inflammation in BCG group was significantly lower than that in control group. These results suggest that BCG vaccination contributes to the treatment of PGN.