目的探讨射频消融术(RFA)联合肝动脉化疗栓塞术(TACE)治疗原发性肝癌的临床疗效。方法采用随机数表法将64例原发性肝癌(肿瘤直径为3~5cm)患者分为两组,每组32例,对照组患者行单纯RFA治疗,观察组患者给予RFA联合TACE治疗,比较两组患者治疗后甲胎蛋白(AFP)水平和卡氏评分,并比较两组患者无瘤生存率。结果两组患者治疗后AFP均明显降低,卡氏评分明显提高,且观察组优于对照组,差异均有统计学意义(均P<0.05)。观察组患者随访期间,2年及3年无瘤生存率均明显高于对照组,差异有统计学意义(P<0.05)。结论 RFA联合TACE治疗原发性肝癌(肿瘤直径3~5 cm)与单纯RFA比较,可进一步提高临床疗效并改善患者的预后。 Objective To investigate the clinical efficacy of radiofrequency catheter ablation (RFA) and transcatheter arterial chemoembolization (TACE) in the treatment of primary liver cancer. Methods 64 patients with primary hepatocellular carcinoma (tumor diameter of 3 ~ 5cm) were divided into two groups (randomized numerical method), 32 patients in each group. Patients in the control group received RFA alone and patients in the observation group received RFA combined with TACE. AFP levels and Karnofsky scores after treatment in both groups were compared, and the tumor-free survival rate was compared between the two groups. Results After treatment, the AFP in both groups were significantly lower, and the Karnofsky scores were significantly higher in the two groups. The difference between the two groups was statistically significant (all P <0.05). During the follow-up period of the observation group, the 2-year and 3-year disease-free survival rates were significantly higher than those in the control group, with significant differences (P <0.05). Conclusion RFA combined with TACE in the treatment of primary liver cancer (tumor diameter 3 ~ 5 cm) compared with simple RFA can further improve the clinical efficacy and improve the prognosis of patients.