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报告1例原发性皮肤CD30~+间变性大细胞淋巴瘤(PC-ALCL)。患者女,58岁。左侧大腿暗红斑及斑块1年余,背部红斑及斑块伴溃疡3个月余。背部皮损组织病理检查:表皮部分坏死,真皮至皮下大量胞质丰富的大淋巴样细胞成片浸润,细胞核呈间变性,其间可见中性粒细胞和嗜酸性粒细胞浸润。免疫组化示大淋巴样细胞强阳性表达CD30,阳性表达CD2、CD3、CD4和多发性骨髓瘤原癌基因(MUM)-1,部分表达CD5和T细胞内抗原(TIA)-1,Ki-67阳性率>95%;而不表达CD8、CD20、CD79α、CD56、EB病毒编码RNA(EBER)和间变型淋巴瘤激酶(ALK)。结合临床及组织病理改变,诊断为PC-ALCL。
One case of primary cutaneous CD30 ~ + anaplastic large cell lymphoma (PC-ALCL) was reported. Female patient, 58 years old. Left thigh dark erythema and plaque more than 1 year, the back of the erythema and plaque with ulcers more than 3 months. Histopathological examination of the back skin lesions: part of the epidermis necrosis, a large number of dermis to the dermis subcutaneous large lymphoid cells into a piece of infiltration, the nucleus showed a degeneration, during which visible neutrophils and eosinophils infiltration. Immunohistochemistry showed that large lymphoid cells strongly expressed CD30, positively expressed CD2, CD3, CD4 and multiple myeloma proto-oncogene (MUM) -1, partially expressed CD5 and T cell intracellular antigen (TIA) 67 positive rate> 95%; but not CD8, CD20, CD79α, CD56, Epstein-Barr virus coding RNA (EBER) and anaplastic lymphoma kinase (ALK). Combined with clinical and histopathological changes, the diagnosis of PC-ALCL.