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目的:观察肝络通对门静脉高压症大鼠内脏血流动力学的影响。方法:应用胆总管结扎的方法制作胆汁性肝硬化门静脉高压症模型。大鼠分为假手术组、模型组、肝络通组。2周后灌胃给药,4周后取材。采用插管的方法测定门静脉压力和平均动脉压力。采用彩色微球技术,测定内脏各组织的血流量、内脏循环血流阻力、门区血流量。结果:治疗后,肝络通可有效降低门静脉压力,升高体循环平均动脉压力,降低门区血流量,提高内脏循环阻力。在降低内脏血流量方面,以降低肠系膜和小肠的血流量作用最为显著。结论:肝络通可有效缓解门静脉高压症高动力循环,这是肝络通降低门静脉压力的机制之一。
Objective: To observe the effect of Ganluo Tong on portal hemodynamics in portal hypertension rats. Methods: The model of biliary cirrhosis and portal hypertension was made by common bile duct ligation. Rats were divided into sham operation group, model group and hepatic collaterals group. Gavage after 2 weeks, 4 weeks after drawing. Intubation was used to measure portal pressure and mean arterial pressure. The technique of color microspheres was used to measure the blood flow of visceral tissues, the blood flow resistance of visceral circulation and the blood flow in the portal area. Results: After treatment, Ganluotong can effectively reduce portal pressure, increase systemic arterial pressure, reduce portal blood flow and improve visceral circulation resistance. In reducing visceral blood flow, to reduce the mesenteric and small intestine, the most significant role in blood flow. Conclusion: Ganluotong can effectively relieve the hyperdynamic circulation of portal hypertension, which is one of the mechanisms by which liver collaterals reduce portal pressure.