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The current study sought to investigate the potential protective action of curcumin against interleukin-6-induced injury in rat hippocampal neurons.The results revealed that interleukin-6 induced typical cellular injury,such as the swelling of cell bodies and increased Ca2+ concentration.After administration of curcumin,interleukin-6-induced neurons recovered to a normal state,and the fluorescence intensity of Ca2+ gradually returned to normal.These findings suggest that curcumin exerts a protective effect on hippocampal neurons of rats.In addition,our results suggest that the protective effect of curcumin involves prevention of the rapid Ca2+ influx induced by interleukin-6,which maintains Ca2+ homeostasis.
The current study sought to investigate the potential protective action of curcumin against interleukin-6-induced injury in rat hippocampal neurons. The results revealed that interleukin-6 induced typical cellular injury, such as the swelling of cell bodies and increased Ca2 concentration. After the administration of curcumin, interleukin-6-induced neurons recovered to a normal state, and the fluorescence intensity of Ca2 + gradually returned to normal. These findings suggest that curcumin exerts a protective effect on hippocampal neurons of rats. In addition, our results suggest that the the protective effect of curcuminults tumors prevention involves the rapid Ca2 + influx induced by interleukin-6, which maintains Ca2 + homeostasis.