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目的探讨腹腔镜手术联合氨蝶呤(MTX)治疗异位妊娠的临床效果,为异位妊娠的治疗提供理论依据。方法回顾性分析2015年10月-2016年9月在该院就诊的50例异位妊娠患者的病历资料,根据治疗方法将患者分为A、B、C 3组。A组16例,采用腹腔镜手术联合甲氨蝶呤注射治疗;B组15例,采用腹腔镜手术治疗;C组19例,采用MTX注射治疗。观察3组患者治疗后包块消失时间、住院时间、月经恢复正常时间、血β-h CG水平变化情况及再次妊娠情况。结果 A组患者的血β-h CG水平下降速度及幅度明显大于其他两组,差异有统计学意义(P<0.05);A组患者持续性异位妊娠发生率明显低于其他两组患者,差异有统计学意义(P<0.05)。结论腹腔镜联合MTX治疗具有融诊断与治疗一体、术后并发症少等优点,可显著提高患者的生殖能力,提高患者的生存质量。
Objective To investigate the clinical effect of laparoscopic surgery combined with methotrexate (MTX) in the treatment of ectopic pregnancy, and to provide a theoretical basis for the treatment of ectopic pregnancy. Methods The clinical data of 50 patients with ectopic pregnancy treated in our hospital from October 2015 to September 2016 were retrospectively analyzed. Patients were divided into groups A, B and C according to the treatment method. A group of 16 cases, laparoscopic surgery combined with methotrexate injection treatment; B group 15 cases, laparoscopic surgery; C group 19 cases, using MTX injection. The disappearance time, hospitalization time, normal menstruation recovery time, change of blood β-h CG level and pregnancy again were observed in 3 groups of patients after treatment. Results The declining speed and amplitude of β-h CG in group A were significantly higher than those in the other two groups (P <0.05). The incidence of persistent ectopic pregnancy in group A was significantly lower than that in the other two groups, The difference was statistically significant (P <0.05). Conclusions Laparoscopic combined with MTX has the advantages of integrating diagnosis and treatment, with less postoperative complications, which can significantly improve the reproductive capacity of patients and improve the quality of life of patients.