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目的:探讨肝素结合蛋白(HBP)与1,25-(OH)_2D_3在慢性阻塞性肺疾病急性加重期(AECOPD)患者血清中的表达水平及临床意义。方法:选择2012年7月至2015年7月广州医科大学附属第五医院收治的82例慢性阻塞性肺疾病患者作为研究对象,其中AECOPD组48例、COPD稳定期组34例。酶联免疫吸附试验测定1,25-(OH)_2D_3、HBP水平,同时检测血清降钙素原(PCT)、超敏C反应蛋白(hs-CRP)及WBC水平,同步行肺功能及相关检查。结果:AECOPD患者HBP水平为(74.15±13.24)ng/m L,明显高于COPD稳定期患者的(51.57±10.22)ng/m L(P<0.05);AECOPD患者1,25-(OH)_2D_3水平为(14.85±5.32)ng/m L,明显低于COPD稳定期患者的(19.46±6.52)ng/m L(P<0.05)。AECOPD患者PCT、hs-CRP及WBC水平均高于COPD稳定期患者(P<0.05),肺功能各项指标均明显低于COPD稳定患者(P<0.05)。血清1,25-(OH)_2D_3与肺功能指标呈正相关,HBP水平与肺功能指标呈负相关(P<0.05)。结论:血清1,25-(OH)_2D_3、HBP可作为AECOPD的辅助诊断指标,二者在COPD气道炎症及重塑中可能具有重要作用。
Objective: To investigate the expression and clinical significance of heparin-binding protein (HBP) and 1,25- (OH) _2D_3 in serum of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: A total of 82 chronic obstructive pulmonary disease patients admitted to the Fifth Affiliated Hospital of Guangzhou Medical University from July 2012 to July 2015 were selected as the study subjects, including 48 patients in the AECOPD group and 34 patients in the stable COPD group. Serum procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP) and WBC levels were detected by enzyme linked immunosorbent assay (ELISA), and the levels of 1,25- (OH) . Results: The level of HBP in AECOPD patients was (74.15 ± 13.24) ng / m L, significantly higher than that in COPD stable patients (51.57 ± 10.22) ng / m L (P <0.05) (14.85 ± 5.32) ng / m L, which was significantly lower than that of patients with stable COPD (19.46 ± 6.52 ng / m L, P <0.05). The levels of PCT, hs-CRP and WBC in patients with AECOPD were significantly higher than those in patients with stable COPD (P <0.05). The indexes of pulmonary function were significantly lower than those with stable COPD (P <0.05). Serum 1,25- (OH) _2D_3 was positively correlated with pulmonary function, while HBP level was negatively correlated with pulmonary function (P <0.05). Conclusion: Serum 1,25- (OH) _2D_3 and HBP can be used as auxiliary diagnostic indicators of AECOPD, both of which may play an important role in airway inflammation and remodeling of COPD.