论文部分内容阅读
用20只成年豚鼠气管,制成多个“Z”形相连气管条,置入含Krebs-Henseleit液的器官浴中,以浴液温度为37℃,通5％CO_2和95％O_2为对照,观察缺O_2(通5％CO_2和95％N_2)、低温(浴液温度为12～15℃)或高CO_2(10％CO_2和90％O_2)对乙酰胆碱和组织胺致痉作用的影响并分析其机制。结果表明:缺O_2使平滑肌对乙酰胆碱和组织胺张力反应速度加快,总张力升高;低温使平滑肌对乙酰胆碱和组织胺张力反应速度减慢,总张力降低;高CO_2不影响平滑肌对组织胺或乙酰胆碱的反应;缺O_2、低温和高CO_2不影响异丙基肾上腺素对乙酰胆碱或组织胺所致痉挛的解痉作用。
A number of “Z” shaped tracheal strips were made from 20 adult guinea pig trachea and placed in an organ bath containing Krebs-Henseleit solution. The bath temperature was 37 ° C, 5% CO_2 and 95% O_2 were used as controls, The effects of O 2 (5% CO 2 and 95% N 2), the low temperature (12 ~ 15 ℃) or high CO 2 (10% CO 2 and 90% O 2) on the spasticity of acetylcholine and histamine were observed and analyzed mechanism. The results showed that the lack of O_2 accelerated the tension response of smooth muscle to acetylcholine and histamine, and the total tension increased. The hypothermia caused the slow response of smooth muscle to acetylcholine and histamine, and decreased the total tension. High CO_2 did not affect smooth muscle to histamine or acetylcholine The lack of O_2, low temperature and high CO_2 does not affect isoproterenol on acetylcholine or histamine spasm caused by antispasmodic effect.