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近年来,越来越多的研究人员开始寻找具有全新作用机制的新抗生素以应对日益严重的抗生素耐药现象。该综述文章主要关注几个最近报道的、可用于化学疗法的AaRS抑制剂的发展前景,并对那些临床分离耐药菌对AaRs抑制剂的主要耐药机制进行阐述,并就如何减少耐药菌株出现的最新策略展开讨论。
In recent years, more and more researchers are looking for new antibiotics with a new mechanism of action to cope with the increasingly serious antibiotic resistance. This review article focuses on the development of several recently reported AaRS inhibitors that may be used in chemotherapy and describes the major mechanisms of resistance to AaRs inhibitors in clinical isolates of resistant bacteria and how to reduce drug-resistant strains The latest strategy emerged to discuss.