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目的 研究糖尿病大鼠胃窦肌间神经丛胆碱能神经及平滑肌组织M2受体改变 ,探讨糖尿病胃轻瘫发病机制。方法 健康 2月大小Wistar大鼠 5 0只随机分为实验组和对照 2组 :实验组Wistar大鼠 30只 ,腹腔内注射链尿佐菌素 6 0mg kg建立鼠糖尿病模型 ;正常对照组 2 0只 ,腹腔内只注射
Objective To investigate the changes of M2 receptors in the cholinergic nerves and smooth muscle of the myenteric ganglion in diabetic rats and to explore the pathogenesis of diabetic gastroparesis. Methods Fifty healthy Wistar rats were randomly divided into two groups: experimental group and control group. 30 Wistar rats in experiment group were injected intraperitoneally with streptozotocin (60 mg) to establish mouse model of diabetes. The normal control group Only intraperitoneal injection