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目的:观察羟苯磺酸钙联合大黄治疗慢性肾脏病的疗效。方法:将180例慢性肾脏病患者随机分为治疗组(羟苯磺酸钙和大黄联合治疗)和对照组(羟苯磺酸钙治疗),每组各90例,观察治疗前和治疗2、48、周后的血肌酐(Scr)、尿素氮(BUN)、肾小球滤过率(GFR)、血脂(TC、TG)及24 h尿蛋白定量(TP/24 h)变化。结果:两组总有效率比较,治疗组优于对照组(P<0.05);治疗组与治疗前比较,口服羟苯磺酸钙和大黄后,Scr、BUN、TC、TG 2周开始下降,持续降低至8周;GFR 2周开始升高持续至8周(P<0.05);TP/24 h没有明显变化(P>0.05)。结论:羟苯磺酸钙联合大黄能够更加有效、安全的延缓慢性肾脏病的进展,且越早干预效果越好。
Objective: To observe the efficacy of calcium dobesilate combined with rhubarb in the treatment of chronic kidney disease. Methods: 180 patients with chronic kidney disease were randomly divided into treatment group (calcium dobesilate and rhubarb combined treatment) and control group (calcium dobesilate), each group of 90 cases, observed before treatment and treatment 2, 48 weeks after operation, and the changes of serum creatinine (Scr), blood urea nitrogen (BUN), glomerular filtration rate (GFR), blood lipid (TC, TG) and 24 h urinary protein (TP / 24 h) Results: The total effective rate of the two groups was better than that of the control group (P <0.05). After treatment with calcium dobesilate and rhubarb, the levels of Scr, BUN, TC and TG in the treatment group began to decline at 2 weeks, (P <0.05). There was no significant change in TP / 24 h (P> 0.05). Conclusion: Combination of calcium dobesilate and rhubarb can delay the progress of chronic kidney disease more effectively and safely, and the sooner the better the intervention is.