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目的探讨肝癌、胃癌、大肠癌发病机理。方法应用生物测定法检测肝癌、胃癌、大肠癌外周血 T 淋巴细胞丝裂原反应性和血浆白细胞介素-2(IL-2)、白细胞介素-6(IL-6)活性及可溶性白细胞介素-2受体(IL-2R)的表达。结果肝癌、胃癌、大肠癌患者 T 淋巴细胞丝裂原反应性和血浆IL-2、IL-6活性均显著低于对照组,而 IL-2R表达却均显著高于对照组。结论肝癌、胃癌、大肠癌患者外周血 T 淋巴细胞功能被严重抑制,IL-2、IL-6和 IL-2R 可能在该病的发病机制中起一定作用。
Objective To explore the pathogenesis of liver cancer, gastric cancer and colorectal cancer. Methods Bioassay was used to detect the mitogen responsiveness of peripheral blood T lymphocytes, plasma interleukin-2 (IL-2), interleukin-6 (IL-6) activity and soluble leukocyte in peripheral blood of patients with liver cancer, gastric cancer and colorectal cancer. Receptor-2 (IL-2R) expression. Results The mitogen reactivity of T lymphocytes and the activity of IL-2 and IL-6 in patients with hepatocellular carcinoma, gastric cancer and colorectal cancer were significantly lower than those in the control group, whereas the expression of IL-2R was significantly higher than that in the control group. Conclusion The function of T lymphocytes in peripheral blood of patients with hepatocellular carcinoma, gastric cancer and colorectal cancer is severely inhibited. IL-2, IL-6 and IL-2R may play a role in the pathogenesis of this disease.