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血管内皮生长因子及其受体都是具有高度生物活性的蛋白因子,配体与受体结合后可以介导血管内皮细胞的分裂增值及促进血管通透性,这些蛋白因子表达非常广泛,不仅在雌性生殖系统中发挥作用而且在雄性生殖系统中也有积极的影响,在雄性生殖系统中主要可调节睾丸、附睾等器官的微环境,而且对精子的发生、形成、成熟有着重要的作用.本文就近年来国内外有关血管内皮生长因子及其主要受体对雄性睾丸、附睾及精子方面的作用作一简要综述.“,”Vascular endothelial growth factor and its receptors are highly bioactive protein factors,ligand and receptor binding can mediate vascular endothelial cell division and promote vascular permeability,these protein expression is very broad,not only in the Female reproductive system play a role in the male reproductive system also has a positive impact in the male reproductive system can be adjusted mainly testis,epididymis and other organs of the microenvironment,but also on the occurrence of sperm,formation,maturity has an important role.In this paper,the effects of VEGF and its receptor in the testis,epididymis and sperm of the male were reviewed in recent years.