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目的:观察甲钴胺对周围神经损害后恢复的影响。方法:以SD大鼠坐骨神经建立周围神经损害动物模型,以坐骨神经传导速度、坐骨神经干病理切片(光镜、电镜)为观察指标,考察甲钴胺对周围神经损害后恢复的影响。结果:甲钴胺组给药4周后能显著改善大鼠坐骨神经损害。结论:甲钴胺对周围神经损害有确切的修复作用。
Objective: To observe the impact of mecobalamin on the recovery of peripheral nerve damage. Methods: The animal model of peripheral nerve injury was established by sciatic nerve in SD rats. The sciatic nerve conduction velocity and pathological section of sciatic nerve trunk (light microscope and electron microscope) were used as the observation indexes to investigate the effect of mecobalamin on the recovery after peripheral nerve injury. Results: The mecobalamin group could significantly improve the sciatic nerve injury in rats after 4 weeks of administration. Conclusion: Mecobalamin has the exact repair effect on peripheral nerve damage.