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目的：研究超氧化物歧化酶（SOD）复合酶在急性肾小球肾炎病程中对肾组织结构和功能的保护作用。方法：诱发大鼠急性肾小球肾炎，并肌注SOD复合酶抗氧化保护性治疗。Wistar大鼠36只，设肾炎组A、酶保护组B、正常对照组C，每组12只。结果：A组大鼠肾组织是急性肾小球肾炎表现，肾小球内有核细胞增生，其细胞数为70.23±3．86个／肾小球，尿蛋白量显著增高为137．65±28．00mg/24小时，肾皮质SOD活性明显降低为513．07±152．82U／g，MDA含量显著增高为197.29±19．72U／g；B组与A组比较，肾组织病变明显减轻。B组上述相应的实验指标分别为肾小球内有核细胞数52．05±2.79个／肾小球、尿蛋白量97．99±15.82mg/24小时、SOD563.46±124.30U／g、MDA149．99±16．19U／g，两组各项指标比较，除SOD外，差异具有显著性意义或极显著性意义。结论：自由基的损伤作用在急性肾小球肾炎发生发展过程中具有重要意义，应用SOD复合酶可改善急性肾小球肾炎病程中肾组织病变，对肾组织结构和功能具有一定的保护作用。
Objective: To study the protective effect of superoxide dismutase (SOD) on the structure and function of kidney in the course of acute glomerulonephritis. Methods: Acute glomerulonephritis was induced in rats and intramuscular injection of SOD complex enzyme anti-oxidative protective treatment. Thirty-six Wistar rats were divided into two groups: nephritis group A, enzyme protection group B and normal control group C, with 12 rats in each group. Results: The renal tissue of group A was acute glomerulonephritis, the number of proliferating glomerulus was 70.23 ± 3.86 / glomerular in glomerulus, and the amount of urinary protein was significantly increased to 137.65 ± 28.00mg / 24 hours, renal cortical SOD activity was significantly reduced to 513.07 ± 152.82U / g, MDA content was significantly increased to 197.29 ± 19.72U / g; B group compared with the A group, renal tissue lesions significantly reduced. The corresponding experimental indexes in group B were as follows: the number of glomerular nucleated cells was 52.05 ± 2.79 / glomerular, the amount of urinary protein was 97.99 ± 15.82mg / 24 hours, SOD was 563.46 ± 124.30U / g, MDA149.99 ± 16.19U / g, the two groups of indicators, in addition to SOD, the difference was significant or extremely significant. CONCLUSION: The injury of free radicals plays an important role in the development of acute glomerulonephritis. The application of SOD complex enzyme can improve the renal tissue pathology in the course of acute glomerulonephritis and protect the renal structure and function.