近年来许多研究表明,牙周炎的发病机制,多形核中性白细胞起重要作用,中性白细胞在吞噬牙斑的细菌、免疫复合物和组织分解产物的过程中,分泌出大量胶原酶、组织蛋白酶和弹性硬蛋白酶,后者聚积在牙周组织病灶,促使炎症加重,并破坏结缔组织。龈炎和牙周炎病人唾液中性白细胞弹性硬蛋白酶活性明显增高,同疾病的严重程度呈正相关。正常 In recent years, many studies have shown that the pathogenesis of periodontitis, polymorphonuclear neutrophils play an important role in neutrophil phagocytosis plaque bacteria, immune complexes and tissue decomposition products in the process, the secretion of a large number of collagenase, Cathepsin and elastase, the latter accumulate in the periodontal tissue lesions, to promote inflammation and destruction of connective tissue. Gingivitis and periodontitis in patients with saliva neutrophil elastase activity was significantly increased, with the severity of the disease was positively correlated. normal