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目的探讨皮肤原发性肥大细胞瘤(CM)的临床病理特征、免疫表型、超微结构及鉴别诊断。方法对2例皮肤原发性肥大细胞瘤进行临床病理学观察、免疫组化及超微结构研究,并复习相关文献。结果 2例患儿均为男性,年龄为4个月和3岁,皮损位于颈部、肩部及右足跟部。镜下见真皮层多量圆形或卵圆形中等大小细胞聚集,异型性不明显,核分裂象未见。免疫组化:瘤细胞CD117(+),CD1a和S-100蛋白(-);甲苯胺蓝染色显示胞质内出现较多紫红色异染颗粒。结论皮肤原发性肥大细胞瘤是好发于儿童的一种少见病,明确该病变的临床病理及免疫表型特征对于诊断及鉴别诊断有重要意义。
Objective To investigate the clinicopathological characteristics, immunophenotype, ultrastructure and differential diagnosis of primary mastocytoma (CM) in skin. Methods Two cases of primary mastocytoma of the skin were observed by clinicopathology, immunohistochemistry and ultrastructure, and the related literatures were reviewed. Results Both of the 2 children were male, aged 4 months and 3 years old. The lesions were located on the neck, shoulder and right heel. Microscope see the dermis a large number of round or oval-shaped cells of medium size, atypia is not obvious, no such as mitosis. Immunohistochemistry: Tumor cells CD117 (+), CD1a and S-100 protein (-); toluidine blue staining showed more purple-colored particles in the cytoplasm. Conclusions Primary mastocytoma of the skin is a rare disease that occurs in children. It is important to clarify the clinicopathological and immunophenotypic features of the lesion in diagnosis and differential diagnosis.