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DNA依赖蛋白激酶(DNA-PK)是哺乳动物细胞DNA损伤修复的关键酶。研究表明,妇科肿瘤,如宫颈癌、卵巢癌中普遍存在DNA-PK表达的变化,提示该酶在妇科肿瘤的发生、发展过程中发挥着重要的作用,并与肿瘤的临床分期、放射敏感性和预后有重要关系。近年来,关于DNA-PK的结构与功能、在肿瘤细胞株中的活性、在肿瘤组织中表达的研究日益深入,以DNA-PK为靶点的DNA修复抑制剂作为肿瘤放化疗增敏药已陆续研发并进入临床前试验,有望成为肿瘤诊断和治疗的新靶点。
DNA-dependent protein kinase (DNA-PK) is a key enzyme in DNA damage repair in mammalian cells. Studies have shown that gynecological tumors, such as cervical cancer, ovarian cancer DNA-PK expression in general changes, suggesting that the enzyme in the gynecologic oncogenesis, development plays an important role, and the clinical stage, radiosensitivity And prognosis have an important relationship. In recent years, DNA-PK on the structure and function of tumor cell lines in the activity of tumor tissue expression in the increasingly in-depth study of DNA-PK as a target of DNA repair inhibitors as a radiotherapy chemosensitizer One after another research and development and into the preclinical test, is expected to become a new target for the diagnosis and treatment of cancer.